Dr. Shaun Murphy, a surgeon with autism and savant syndrome, continues to use his extraordinary medical gifts at St. Bonaventure Hospital's surgical unit. Following their long-awaited wedding festivities and his promotion to surgical attending, Shaun and Lea's relationship is immediately put to the test and they must learn to navigate life together as a married couple. Meanwhile, the team is dealing with changes at the hospital and in their personal lives that will present new emotional and interpersonal challenges for them.