Trail guide Kirk Douglas agrees to shepherd a wagon train through Sioux territory. Douglas tries to convince the Sioux to leave his charges alone, but such hot-heads as drunken white trader Walter Matthau and embittered Indian brave Harry Landers escalate the tensions. Douglas is forced to go "mano y mano" with Landers; Douglas wins, but refuses to kill Landers, having lost his taste for killing. But when Matthau and his partner Lon Chaney Jr. contrive to rob the Indians of their gold, Sioux chief Eduard Franz prepares to wipe out the settlers. Only when Douglas risks life and limb to bring Matthau and Chaney Jr. to justice does Franz relent.
